diff --git a/esphome/components/tca9555/__init__.py b/esphome/components/tca9555/__init__.py
index f42e0fe398..5f571fcea6 100644
--- a/esphome/components/tca9555/__init__.py
+++ b/esphome/components/tca9555/__init__.py
@@ -5,6 +5,7 @@ import esphome.config_validation as cv
 from esphome.const import (
     CONF_ID,
     CONF_INPUT,
+    CONF_INTERRUPT_PIN,
     CONF_INVERTED,
     CONF_MODE,
     CONF_NUMBER,
@@ -27,6 +28,7 @@ CONFIG_SCHEMA = (
     cv.Schema(
         {
             cv.Required(CONF_ID): cv.declare_id(TCA9555Component),
+            cv.Optional(CONF_INTERRUPT_PIN): pins.internal_gpio_input_pin_schema,
         }
     )
     .extend(cv.COMPONENT_SCHEMA)
@@ -38,6 +40,8 @@ async def to_code(config):
     var = cg.new_Pvariable(config[CONF_ID])
     await cg.register_component(var, config)
     await i2c.register_i2c_device(var, config)
+    if interrupt_pin := config.get(CONF_INTERRUPT_PIN):
+        cg.add(var.set_interrupt_pin(await cg.gpio_pin_expression(interrupt_pin)))
 
 
 def validate_mode(value):
diff --git a/esphome/components/tca9555/tca9555.cpp b/esphome/components/tca9555/tca9555.cpp
index 79c5253898..3eb794df44 100644
--- a/esphome/components/tca9555/tca9555.cpp
+++ b/esphome/components/tca9555/tca9555.cpp
@@ -24,9 +24,18 @@ void TCA9555Component::setup() {
     this->mark_failed();
     return;
   }
+
+  if (this->interrupt_pin_ != nullptr) {
+    this->interrupt_pin_->setup();
+    this->interrupt_pin_->attach_interrupt(&TCA9555Component::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
+    this->set_invalidate_on_read_(false);
+  }
+  this->disable_loop();
 }
+void IRAM_ATTR TCA9555Component::gpio_intr(TCA9555Component *arg) { arg->enable_loop_soon_any_context(); }
 void TCA9555Component::dump_config() {
   ESP_LOGCONFIG(TAG, "TCA9555:");
+  LOG_PIN("  Interrupt Pin: ", this->interrupt_pin_);
   LOG_I2C_DEVICE(this)
   if (this->is_failed()) {
     ESP_LOGE(TAG, ESP_LOG_MSG_COMM_FAIL);
@@ -36,6 +45,9 @@ void TCA9555Component::pin_mode(uint8_t pin, gpio::Flags flags) {
   if (flags == gpio::FLAG_INPUT) {
     // Set mode mask bit
     this->mode_mask_ |= 1 << pin;
+    if (this->interrupt_pin_ == nullptr) {
+      this->enable_loop();
+    }
   } else if (flags == gpio::FLAG_OUTPUT) {
     // Clear mode mask bit
     this->mode_mask_ &= ~(1 << pin);
@@ -43,7 +55,12 @@ void TCA9555Component::pin_mode(uint8_t pin, gpio::Flags flags) {
   // Write GPIO to enable input mode
   this->write_gpio_modes_();
 }
-void TCA9555Component::loop() { this->reset_pin_cache_(); }
+void TCA9555Component::loop() {
+  this->reset_pin_cache_();
+  if (this->interrupt_pin_ != nullptr) {
+    this->disable_loop();
+  }
+}
 
 bool TCA9555Component::read_gpio_outputs_() {
   if (this->is_failed())
diff --git a/esphome/components/tca9555/tca9555.h b/esphome/components/tca9555/tca9555.h
index 9f7273b1e7..d4d070013c 100644
--- a/esphome/components/tca9555/tca9555.h
+++ b/esphome/components/tca9555/tca9555.h
@@ -24,7 +24,10 @@ class TCA9555Component : public Component,
 
   void loop() override;
 
+  void set_interrupt_pin(InternalGPIOPin *pin) { this->interrupt_pin_ = pin; }
+
  protected:
+  static void IRAM_ATTR gpio_intr(TCA9555Component *arg);
   bool digital_read_hw(uint8_t pin) override;
   bool digital_read_cache(uint8_t pin) override;
   void digital_write_hw(uint8_t pin, bool value) override;
@@ -39,6 +42,8 @@ class TCA9555Component : public Component,
   bool read_gpio_modes_();
   bool write_gpio_modes_();
   bool read_gpio_outputs_();
+
+  InternalGPIOPin *interrupt_pin_{nullptr};
 };
 
 /// Helper class to expose a TCA9555 pin as an internal input GPIO pin.
diff --git a/tests/components/tca9555/common.yaml b/tests/components/tca9555/common.yaml
index 82b4c959d8..d1a68c575a 100644
--- a/tests/components/tca9555/common.yaml
+++ b/tests/components/tca9555/common.yaml
@@ -2,6 +2,10 @@ tca9555:
   - id: tca9555_hub
     i2c_id: i2c_bus
     address: 0x21
+  - id: tca9555_hub_int
+    i2c_id: i2c_bus
+    address: 0x22
+    interrupt_pin: ${interrupt_pin}
 
 binary_sensor:
   - platform: gpio
diff --git a/tests/components/tca9555/test.esp32-idf.yaml b/tests/components/tca9555/test.esp32-idf.yaml
index b47e39c389..8c3b341dce 100644
--- a/tests/components/tca9555/test.esp32-idf.yaml
+++ b/tests/components/tca9555/test.esp32-idf.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
 
diff --git a/tests/components/tca9555/test.esp8266-ard.yaml b/tests/components/tca9555/test.esp8266-ard.yaml
index 4a98b9388a..69b243bfd8 100644
--- a/tests/components/tca9555/test.esp8266-ard.yaml
+++ b/tests/components/tca9555/test.esp8266-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp8266-ard.yaml
 
diff --git a/tests/components/tca9555/test.rp2040-ard.yaml b/tests/components/tca9555/test.rp2040-ard.yaml
index 319a7c71a6..b8ad1e4792 100644
--- a/tests/components/tca9555/test.rp2040-ard.yaml
+++ b/tests/components/tca9555/test.rp2040-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO2
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml