diff --git a/esphome/espidf/toolchain.py b/esphome/espidf/toolchain.py
index e1688f4170..bb6452acf2 100644
--- a/esphome/espidf/toolchain.py
+++ b/esphome/espidf/toolchain.py
@@ -109,6 +109,8 @@ def _get_idf_env(version: str | None = None) -> dict[str, str]:
     env_cache = _cache().env
     if version not in env_cache:
         env_cache[version] = os.environ.copy()
+        # Do not leak PYTHONPATH into child env
+        env_cache[version].pop("PYTHONPATH", None)
 
         # Use provided IDF framework if available
         if "IDF_PATH" not in os.environ:
diff --git a/esphome/framework_helpers.py b/esphome/framework_helpers.py
index 86d5e4eaea..b8a43220ff 100644
--- a/esphome/framework_helpers.py
+++ b/esphome/framework_helpers.py
@@ -155,6 +155,8 @@ def run_command(
         _LOGGER.debug("%s - running ...", cmd_str)
 
         run_env = os.environ.copy()
+        # Do not leak PYTHONPATH
+        run_env.pop("PYTHONPATH", None)
         if env:
             run_env.update(env)
 
diff --git a/tests/unit_tests/test_espidf_toolchain.py b/tests/unit_tests/test_espidf_toolchain.py
index 56f358a24c..26d812af8b 100644
--- a/tests/unit_tests/test_espidf_toolchain.py
+++ b/tests/unit_tests/test_espidf_toolchain.py
@@ -265,6 +265,21 @@ def test_get_idf_env_sets_git_ceiling_directories(setup_core: Path) -> None:
     assert str(CORE.config_dir) in env["GIT_CEILING_DIRECTORIES"].split(os.pathsep)
 
 
+def test_get_idf_env_pops_inherited_pythonpath(setup_core: Path) -> None:
+    """A PYTHONPATH from the parent environment must not reach idf.py.
+
+    It would override the IDF venv's isolation, shadowing its pinned
+    packages and failing idf.py's dependency check.
+    """
+    toolchain._cache().env.clear()
+    with patch.dict(
+        os.environ,
+        {"IDF_PATH": str(setup_core), "PYTHONPATH": "/outside/site-packages"},
+    ):
+        env = toolchain._get_idf_env(version="5.5.4")
+    assert "PYTHONPATH" not in env
+
+
 def test_get_cmake_output_without_build_dir(setup_core: Path) -> None:
     """A build dir that was never created raises EsphomeError.
 
diff --git a/tests/unit_tests/test_framework_helpers.py b/tests/unit_tests/test_framework_helpers.py
index 7451ee9b39..2022c15bfe 100644
--- a/tests/unit_tests/test_framework_helpers.py
+++ b/tests/unit_tests/test_framework_helpers.py
@@ -188,6 +188,24 @@ def test_run_command_passes_env(mock_subprocess_run: Mock) -> None:
     assert mock_subprocess_run.call_args[1]["env"]["MY_VAR"] == "42"
 
 
+def test_run_command_pops_inherited_pythonpath(mock_subprocess_run: Mock) -> None:
+    """A PYTHONPATH from the parent environment must not leak into subprocesses."""
+    mock_subprocess_run.return_value = Mock(returncode=0, stdout="", stderr="")
+    with patch.dict(os.environ, {"PYTHONPATH": "/outside/site-packages"}):
+        run_command(["cmd"])
+    assert "PYTHONPATH" not in mock_subprocess_run.call_args[1]["env"]
+
+
+def test_run_command_env_pythonpath_preferred_over_pop(
+    mock_subprocess_run: Mock,
+) -> None:
+    """A PYTHONPATH set explicitly via ``env`` is passed through."""
+    mock_subprocess_run.return_value = Mock(returncode=0, stdout="", stderr="")
+    with patch.dict(os.environ, {"PYTHONPATH": "/outside/site-packages"}):
+        run_command(["cmd"], env={"PYTHONPATH": "/idf/tools"})
+    assert mock_subprocess_run.call_args[1]["env"]["PYTHONPATH"] == "/idf/tools"
+
+
 def test_run_command_passes_cwd(mock_subprocess_run: Mock, tmp_path: Path) -> None:
     mock_subprocess_run.return_value = Mock(returncode=0, stdout="", stderr="")
     run_command(["cmd"], cwd=str(tmp_path))