diff --git a/esphome/components/mcp23x08_base/mcp23x08_base.cpp b/esphome/components/mcp23x08_base/mcp23x08_base.cpp
index 92228be62c9..e4f4d50aae1 100644
--- a/esphome/components/mcp23x08_base/mcp23x08_base.cpp
+++ b/esphome/components/mcp23x08_base/mcp23x08_base.cpp
@@ -32,6 +32,11 @@ void MCP23X08Base::pin_mode(uint8_t pin, gpio::Flags flags) {
   } else if (flags == gpio::FLAG_OUTPUT) {
     this->update_reg(pin, false, iodir);
   }
+  // When interrupt_pin is configured, auto-enable CHANGE interrupt for input pins
+  // so the chip's INT output fires on any input state change
+  if (this->interrupt_pin_ != nullptr && (flags & gpio::FLAG_INPUT)) {
+    this->pin_interrupt_mode(pin, mcp23xxx_base::MCP23XXX_CHANGE);
+  }
 }
 
 void MCP23X08Base::pin_interrupt_mode(uint8_t pin, mcp23xxx_base::MCP23XXXInterruptMode interrupt_mode) {
diff --git a/esphome/components/mcp23x17_base/mcp23x17_base.cpp b/esphome/components/mcp23x17_base/mcp23x17_base.cpp
index 6f95ee98fdb..42613053de7 100644
--- a/esphome/components/mcp23x17_base/mcp23x17_base.cpp
+++ b/esphome/components/mcp23x17_base/mcp23x17_base.cpp
@@ -44,6 +44,11 @@ void MCP23X17Base::pin_mode(uint8_t pin, gpio::Flags flags) {
   } else if (flags == gpio::FLAG_OUTPUT) {
     this->update_reg(pin, false, iodir);
   }
+  // When interrupt_pin is configured, auto-enable CHANGE interrupt for input pins
+  // so the chip's INT output fires on any input state change
+  if (this->interrupt_pin_ != nullptr && (flags & gpio::FLAG_INPUT)) {
+    this->pin_interrupt_mode(pin, mcp23xxx_base::MCP23XXX_CHANGE);
+  }
 }
 
 void MCP23X17Base::pin_interrupt_mode(uint8_t pin, mcp23xxx_base::MCP23XXXInterruptMode interrupt_mode) {
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
index 4155e52b393..b09567ba1e1 100644
--- a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
@@ -156,6 +156,13 @@ bool PI4IOE5V6408Component::write_gpio_modes_() {
     this->status_set_warning(LOG_STR("Failed to write GPIO pull enable"));
     return false;
   }
+  // Enable interrupts for input pins when interrupt pin is configured
+  // (input pins have mode_mask_ bit cleared)
+  if (this->interrupt_pin_ != nullptr &&
+      !this->write_byte(PI4IOE5V6408_REGISTER_INTERRUPT_ENABLE_MASK, ~this->mode_mask_)) {
+    this->status_set_warning(LOG_STR("Failed to write interrupt enable mask"));
+    return false;
+  }
 #if ESPHOME_LOG_LEVEL >= ESPHOME_LOG_LEVEL_VERBOSE
   ESP_LOGV(TAG,
            "Wrote GPIO config:\n"