diff --git a/esphome/components/usb_uart/cp210x.cpp b/esphome/components/usb_uart/cp210x.cpp
index 67fd03a813..2c341313db 100644
--- a/esphome/components/usb_uart/cp210x.cpp
+++ b/esphome/components/usb_uart/cp210x.cpp
@@ -120,6 +120,32 @@ void USBUartTypeCP210X::enable_channels() {
   }
   this->start_channels_();
 }
+
+void USBUartTypeCP210X::load_settings(USBUartChannel *channel, bool dump_config) {
+  if (channel == nullptr || !channel->initialised_.load())
+    return;
+
+  usb_host::transfer_cb_t callback = [channel](const usb_host::TransferStatus &status) {
+    if (!status.success) {
+      ESP_LOGE(TAG, "Control transfer failed, status=%s", esp_err_to_name(status.error_code));
+      channel->initialised_.store(false);
+    }
+  };
+
+  uint16_t line_control = channel->stop_bits_;
+  line_control |= static_cast<uint8_t>(channel->parity_) << 4;
+  line_control |= channel->data_bits_ << 8;
+  this->control_transfer(USB_VENDOR_IFC | usb_host::USB_DIR_OUT, SET_LINE_CTL, line_control, channel->index_,
+                         callback);
+
+  auto baud = ByteBuffer::wrap(channel->baud_rate_, LITTLE);
+  this->control_transfer(USB_VENDOR_IFC | usb_host::USB_DIR_OUT, SET_BAUDRATE, 0, channel->index_, callback,
+                         baud.get_data());
+
+  if (dump_config) {
+    ESP_LOGCONFIG(TAG, "UART settings reloaded for CP210X channel %u", channel->index_);
+  }
+}
 }  // namespace esphome::usb_uart
 
 #endif  // USE_ESP32_VARIANT_ESP32P4 || USE_ESP32_VARIANT_ESP32S2 || USE_ESP32_VARIANT_ESP32S3
diff --git a/esphome/components/usb_uart/usb_uart.cpp b/esphome/components/usb_uart/usb_uart.cpp
index 3fdf35a472..7388484fcd 100644
--- a/esphome/components/usb_uart/usb_uart.cpp
+++ b/esphome/components/usb_uart/usb_uart.cpp
@@ -209,7 +209,21 @@ bool USBUartChannel::read_array(uint8_t *data, size_t len) {
   this->parent_->start_input(this);
   return status;
 }
+#if defined(USE_ESP8266) || defined(USE_ESP32)
+void USBUartChannel::load_settings(bool dump_config) {
+  if (this->parent_ == nullptr || !this->initialised_.load())
+    return;
+  this->parent_->load_settings(this, dump_config);
+}
+
+void USBUartChannel::load_settings() { this->load_settings(true); }
+#endif
+
 void USBUartComponent::setup() { USBClient::setup(); }
+void USBUartComponent::load_settings(USBUartChannel *channel, bool dump_config) {
+  (void) channel;
+  (void) dump_config;
+}
 void USBUartComponent::loop() {
   bool had_work = this->process_usb_events_();
 
diff --git a/esphome/components/usb_uart/usb_uart.h b/esphome/components/usb_uart/usb_uart.h
index 41dc2c546d..345eec2664 100644
--- a/esphome/components/usb_uart/usb_uart.h
+++ b/esphome/components/usb_uart/usb_uart.h
@@ -149,6 +149,10 @@ class USBUartChannel : public uart::UARTComponent, public Parented<USBUartCompon
   void set_dummy_receiver(bool dummy_receiver) { this->dummy_receiver_ = dummy_receiver; }
   void set_debug_prefix(const char *prefix) { this->debug_prefix_ = StringRef(prefix); }
   void set_flush_timeout(uint32_t flush_timeout_ms) override { this->flush_timeout_ms_ = flush_timeout_ms; }
+#if defined(USE_ESP8266) || defined(USE_ESP32)
+  void load_settings(bool dump_config) override;
+  void load_settings() override;
+#endif
 
   /// Register a callback invoked immediately after data is pushed to the input ring buffer.
   /// Called from USBUartComponent::loop() in the main loop context.
@@ -188,6 +192,7 @@ class USBUartComponent : public usb_host::USBClient {
   std::vector<USBUartChannel *> get_channels() { return this->channels_; }
 
   void add_channel(USBUartChannel *channel) { this->channels_.push_back(channel); }
+  virtual void load_settings(USBUartChannel *channel, bool dump_config);
 
   void start_input(USBUartChannel *channel);
   void start_output(USBUartChannel *channel);
@@ -224,6 +229,7 @@ class USBUartTypeCP210X : public USBUartTypeCdcAcm {
  protected:
   std::vector<CdcEps> parse_descriptors(usb_device_handle_t dev_hdl) override;
   void enable_channels() override;
+  void load_settings(USBUartChannel *channel, bool dump_config) override;
 };
 class USBUartTypeCH34X : public USBUartTypeCdcAcm {
  public: