diff --git a/esphome/components/usb_host/__init__.py b/esphome/components/usb_host/__init__.py
index 5aa3763f03..213f16286d 100644
--- a/esphome/components/usb_host/__init__.py
+++ b/esphome/components/usb_host/__init__.py
@@ -68,13 +68,11 @@ def validate_usb_clients(configs: list[ConfigType]) -> list[ConfigType]:
     for index, first in enumerate(configs):
         # Ensure matching logic does not overlap between entries
         for second in configs[index + 1 :]:
-            if (
-                not (first[CONF_VID] == 0 and first[CONF_PID] == 0)
-                and not (second[CONF_VID] == 0 and second[CONF_PID] == 0)
-                and (
-                    first[CONF_VID] != second[CONF_VID]
-                    or first[CONF_PID] != second[CONF_PID]
-                )
+            # A zero VID or PID is a wildcard for that field, so only a differing non-zero
+            # value separates two entries
+            if not all(
+                first[key] == 0 or second[key] == 0 or first[key] == second[key]
+                for key in (CONF_VID, CONF_PID)
             ):
                 continue
 
diff --git a/esphome/components/usb_host/usb_host_client.cpp b/esphome/components/usb_host/usb_host_client.cpp
index 76daf68b02..58914ced6e 100644
--- a/esphome/components/usb_host/usb_host_client.cpp
+++ b/esphome/components/usb_host/usb_host_client.cpp
@@ -355,12 +355,10 @@ void USBClient::handle_open_state_() {
     return;
   }
   ESP_LOGD(TAG, "Device descriptor: vid %X pid %X", desc->idVendor, desc->idProduct);
-  if (desc->idVendor != this->vid_ || desc->idProduct != this->pid_) {
-    if (this->vid_ != 0 || this->pid_ != 0) {
-      ESP_LOGD(TAG, "Not our device, closing");
-      this->disconnect();
-      return;
-    }
+  if ((this->vid_ != 0 && desc->idVendor != this->vid_) || (this->pid_ != 0 && desc->idProduct != this->pid_)) {
+    ESP_LOGD(TAG, "Not our device, closing");
+    this->disconnect();
+    return;
   }
   usb_device_info_t dev_info;
   err = usb_host_device_info(this->device_handle_, &dev_info);
diff --git a/tests/unit_tests/components/test_usb_host.py b/tests/unit_tests/components/test_usb_host.py
index 3d6b8dc1c0..39deec1f51 100644
--- a/tests/unit_tests/components/test_usb_host.py
+++ b/tests/unit_tests/components/test_usb_host.py
@@ -70,6 +70,36 @@ from esphome.types import ConfigType
             },
             id="different_manufacturer",
         ),
+        pytest.param(
+            {
+                "id": "a",
+                "vid": 0x303A,
+                "pid": 0,
+                "manufacturer": "Nabu Casa",
+                "product": "ZBT-2",
+            },
+            {
+                "id": "b",
+                "vid": 0x303A,
+                "pid": 0x4001,
+                "manufacturer": "Nabu Casa",
+                "product": "ZWA-2",
+            },
+            id="wildcard_pid_separated_by_product",
+        ),
+        pytest.param(
+            {
+                "id": "a",
+                "vid": 0,
+                "pid": 0x4001,
+            },
+            {
+                "id": "b",
+                "vid": 0x303A,
+                "pid": 0x4002,
+            },
+            id="wildcard_vid_different_pid",
+        ),
     ],
 )
 def test_disjoint_clients_are_accepted(first: ConfigType, second: ConfigType) -> None:
@@ -140,6 +170,34 @@ def test_disjoint_clients_are_accepted(first: ConfigType, second: ConfigType) ->
             },
             id="zero_ids_match_every_device",
         ),
+        pytest.param(
+            {
+                "id": "a",
+                "vid": 0x303A,
+                "pid": 0,
+            },
+            {
+                "id": "b",
+                "vid": 0x303A,
+                "pid": 0x4001,
+                "manufacturer": "Nabu Casa",
+                "product": "ZBT-2",
+            },
+            id="wildcard_pid_shadows_filtered",
+        ),
+        pytest.param(
+            {
+                "id": "a",
+                "vid": 0,
+                "pid": 0x4001,
+            },
+            {
+                "id": "b",
+                "vid": 0x303A,
+                "pid": 0,
+            },
+            id="wildcards_on_different_fields",
+        ),
     ],
 )
 def test_overlapping_clients_are_rejected(