diff --git a/esphome/components/gpio/binary_sensor/__init__.py b/esphome/components/gpio/binary_sensor/__init__.py
index 7cc16eb5b2..8a40e4e732 100644
--- a/esphome/components/gpio/binary_sensor/__init__.py
+++ b/esphome/components/gpio/binary_sensor/__init__.py
@@ -133,6 +133,7 @@ async def to_code(config: ConfigType) -> None:
     cg.add(var.set_pin(pin))
 
     if config[CONF_USE_INTERRUPT]:
+        cg.add_define("USE_GPIO_BINARY_SENSOR_INTERRUPT")
         cg.add(var.set_interrupt_type(config[CONF_INTERRUPT_TYPE]))
     else:
         cg.add(var.set_use_interrupt(False))
diff --git a/esphome/components/gpio/binary_sensor/gpio_binary_sensor.cpp b/esphome/components/gpio/binary_sensor/gpio_binary_sensor.cpp
index ff07d76901..9d044dca2d 100644
--- a/esphome/components/gpio/binary_sensor/gpio_binary_sensor.cpp
+++ b/esphome/components/gpio/binary_sensor/gpio_binary_sensor.cpp
@@ -7,6 +7,7 @@ namespace esphome::gpio {
 static const char *const TAG = "gpio.binary_sensor";
 
 #if ESPHOME_LOG_LEVEL >= ESPHOME_LOG_LEVEL_DEBUG
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
 // Interrupt type strings indexed by edge-triggered InterruptType values:
 // indices 1-3: RISING_EDGE, FALLING_EDGE, ANY_EDGE; other values (e.g. level-triggered) map to UNKNOWN (index 0).
 PROGMEM_STRING_TABLE(InterruptTypeStrings, "UNKNOWN", "RISING_EDGE", "FALLING_EDGE", "ANY_EDGE");
@@ -19,7 +20,9 @@ static const LogString *gpio_mode_to_string(bool use_interrupt) {
   return use_interrupt ? LOG_STR("interrupt") : LOG_STR("polling");
 }
 #endif
+#endif
 
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
 void IRAM_ATTR GPIOBinarySensorStore::gpio_intr(GPIOBinarySensorStore *arg) {
   bool new_state = arg->isr_pin_.digital_read();
   if (new_state != arg->state_) {
@@ -43,28 +46,36 @@ void GPIOBinarySensorStore::setup(InternalGPIOPin *pin, Component *component) {
   // Attach interrupt - from this point on, any changes will be caught by the interrupt
   pin->attach_interrupt(&GPIOBinarySensorStore::gpio_intr, this, this->interrupt_type_);
 }
+#endif  // USE_GPIO_BINARY_SENSOR_INTERRUPT
 
 void GPIOBinarySensor::setup() {
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   if (this->store_.use_interrupt_) {
     auto *internal_pin = static_cast<InternalGPIOPin *>(this->pin_);
     this->store_.setup(internal_pin, this);
     this->publish_initial_state(this->store_.get_state());
-  } else {
-    this->pin_->setup();
-    this->publish_initial_state(this->pin_->digital_read());
+    return;
   }
+#endif
+  this->pin_->setup();
+  this->publish_initial_state(this->pin_->digital_read());
 }
 
 void GPIOBinarySensor::dump_config() {
   LOG_BINARY_SENSOR("", "GPIO Binary Sensor", this);
   LOG_PIN("  Pin: ", this->pin_);
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   ESP_LOGCONFIG(TAG, "  Mode: %s", LOG_STR_ARG(gpio_mode_to_string(this->store_.use_interrupt_)));
   if (this->store_.use_interrupt_) {
     ESP_LOGCONFIG(TAG, "  Interrupt Type: %s", LOG_STR_ARG(interrupt_type_to_string(this->store_.interrupt_type_)));
   }
+#else
+  ESP_LOGCONFIG(TAG, "  Mode: polling");
+#endif
 }
 
 void GPIOBinarySensor::loop() {
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   if (this->store_.use_interrupt_) {
     if (this->store_.is_changed()) {
       // Clear the flag immediately to minimize the window where we might miss changes
@@ -78,9 +89,10 @@ void GPIOBinarySensor::loop() {
       // No changes, disable the loop until the next interrupt
       this->disable_loop();
     }
-  } else {
-    this->publish_state(this->pin_->digital_read());
+    return;
   }
+#endif
+  this->publish_state(this->pin_->digital_read());
 }
 
 float GPIOBinarySensor::get_setup_priority() const { return setup_priority::HARDWARE; }
diff --git a/esphome/components/gpio/binary_sensor/gpio_binary_sensor.h b/esphome/components/gpio/binary_sensor/gpio_binary_sensor.h
index 100edb4cca..956443fab5 100644
--- a/esphome/components/gpio/binary_sensor/gpio_binary_sensor.h
+++ b/esphome/components/gpio/binary_sensor/gpio_binary_sensor.h
@@ -1,6 +1,7 @@
 #pragma once
 
 #include "esphome/core/component.h"
+#include "esphome/core/defines.h"
 #include "esphome/core/hal.h"
 #include "esphome/core/helpers.h"
 #include "esphome/components/binary_sensor/binary_sensor.h"
@@ -10,6 +11,7 @@ namespace esphome::gpio {
 // Store class for ISR data and configuration (no vtables, ISR-safe)
 class GPIOBinarySensorStore {
  public:
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   void setup(InternalGPIOPin *pin, Component *component);
 
   static void gpio_intr(GPIOBinarySensorStore *arg);
@@ -29,15 +31,18 @@ class GPIOBinarySensorStore {
     // Separate method to clear the flag
     this->changed_ = false;
   }
+#endif
 
  protected:
   friend class GPIOBinarySensor;
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   ISRInternalGPIOPin isr_pin_;
   Component *component_{nullptr};  // Pointer to the component for enable_loop_soon_any_context()
   volatile bool state_{false};
   volatile bool changed_{false};
-  bool use_interrupt_{true};
   gpio::InterruptType interrupt_type_{gpio::INTERRUPT_ANY_EDGE};
+  bool use_interrupt_{true};
+#endif
 };
 
 class GPIOBinarySensor final : public binary_sensor::BinarySensor, public Component {
@@ -46,8 +51,14 @@ class GPIOBinarySensor final : public binary_sensor::BinarySensor, public Compon
   // Interrupts are only detached on reboot when memory is cleared anyway.
 
   void set_pin(GPIOPin *pin) { this->pin_ = pin; }
+#ifdef USE_GPIO_BINARY_SENSOR_INTERRUPT
   void set_use_interrupt(bool use_interrupt) { this->store_.use_interrupt_ = use_interrupt; }
   void set_interrupt_type(gpio::InterruptType type) { this->store_.interrupt_type_ = type; }
+#else
+  // Polling-only build: codegen still emits set_use_interrupt(false) calls,
+  // so keep the setter as an inlined no-op instead of storing the flag.
+  void set_use_interrupt(bool /*use_interrupt*/) {}
+#endif
   // ========== INTERNAL METHODS ==========
   // (In most use cases you won't need these)
   /// Setup pin
diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index 5f34437145..42da0191ed 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -72,6 +72,7 @@
 #define USE_ESP32_IMPROV_STATE_CALLBACK
 #define USE_EVENT
 #define USE_FAN
+#define USE_GPIO_BINARY_SENSOR_INTERRUPT
 #define USE_GPIO_SWITCH_INTERLOCK
 #define USE_GRAPH
 #define USE_GRAPHICAL_DISPLAY_MENU
diff --git a/tests/component_tests/gpio/test_gpio_binary_sensor.py b/tests/component_tests/gpio/test_gpio_binary_sensor.py
index f336a9105e..60494d9cba 100644
--- a/tests/component_tests/gpio/test_gpio_binary_sensor.py
+++ b/tests/component_tests/gpio/test_gpio_binary_sensor.py
@@ -3,10 +3,15 @@
 from __future__ import annotations
 
 from collections.abc import Callable
+import logging
 from pathlib import Path
 
 import pytest
 
+from esphome.core import CORE
+
+INTERRUPT_DEFINE = "USE_GPIO_BINARY_SENSOR_INTERRUPT"
+
 
 def test_gpio_binary_sensor_basic_setup(
     generate_main: Callable[[str | Path], str],
@@ -69,3 +74,62 @@ def test_gpio_binary_sensor_explicit_polling_mode(
     )
 
     assert "bs_polling->set_use_interrupt(false);" in main_cpp
+
+
+def test_gpio_binary_sensor_interrupt_emits_define(
+    generate_main: Callable[[str | Path], str],
+) -> None:
+    """
+    An interrupt-mode sensor must emit the define that compiles the ISR code,
+    since the platform ISR pin implementation is only built when needed
+    """
+    generate_main("tests/component_tests/gpio/test_gpio_binary_sensor.yaml")
+
+    assert INTERRUPT_DEFINE in {d.name for d in CORE.defines}
+
+
+def test_gpio_binary_sensor_polling_omits_define(
+    generate_main: Callable[[str | Path], str],
+) -> None:
+    """
+    A polling-only config must not emit the interrupt define, so the ISR code
+    (and its reference to ISRInternalGPIOPin) is compiled out
+    """
+    generate_main("tests/component_tests/gpio/test_gpio_binary_sensor_polling.yaml")
+
+    assert INTERRUPT_DEFINE not in {d.name for d in CORE.defines}
+
+
+def test_gpio_binary_sensor_mixed_modes_emit_define(
+    generate_main: Callable[[str | Path], str],
+) -> None:
+    """
+    With one interrupt and one polling sensor, the define is emitted and the
+    polling instance still opts out via its setter
+    """
+    main_cpp = generate_main(
+        "tests/component_tests/gpio/test_gpio_binary_sensor_mixed.yaml"
+    )
+
+    assert INTERRUPT_DEFINE in {d.name for d in CORE.defines}
+    assert "bs_polling->set_use_interrupt(false);" in main_cpp
+    assert "bs_interrupt->set_use_interrupt" not in main_cpp
+
+
+def test_gpio_binary_sensor_expander_pin_omits_define(
+    generate_main: Callable[[str | Path], str],
+    caplog: pytest.LogCaptureFixture,
+) -> None:
+    """
+    An expander pin can't use interrupts: final validation falls back to
+    polling and the interrupt define must not be emitted. This is the config
+    that fails to link if the ISR code is compiled without an internal pin
+    """
+    with caplog.at_level(logging.INFO):
+        main_cpp = generate_main(
+            "tests/component_tests/gpio/test_gpio_binary_sensor_expander.yaml"
+        )
+
+    assert "bs_expander->set_use_interrupt(false);" in main_cpp
+    assert INTERRUPT_DEFINE not in {d.name for d in CORE.defines}
+    assert "falling back to polling mode" in caplog.text
diff --git a/tests/component_tests/gpio/test_gpio_binary_sensor_expander.yaml b/tests/component_tests/gpio/test_gpio_binary_sensor_expander.yaml
new file mode 100644
index 0000000000..f153ccebfd
--- /dev/null
+++ b/tests/component_tests/gpio/test_gpio_binary_sensor_expander.yaml
@@ -0,0 +1,21 @@
+esphome:
+  name: test
+
+esp32:
+  board: esp32dev
+
+i2c:
+  scl: 16
+  sda: 17
+
+ch422g:
+  - id: ch422g_hub
+
+binary_sensor:
+  - platform: gpio
+    name: "Expander Sensor"
+    id: bs_expander
+    pin:
+      ch422g: ch422g_hub
+      number: 1
+      mode: INPUT
diff --git a/tests/component_tests/gpio/test_gpio_binary_sensor_mixed.yaml b/tests/component_tests/gpio/test_gpio_binary_sensor_mixed.yaml
new file mode 100644
index 0000000000..0e8c7ec3fd
--- /dev/null
+++ b/tests/component_tests/gpio/test_gpio_binary_sensor_mixed.yaml
@@ -0,0 +1,17 @@
+esphome:
+  name: test
+
+esp32:
+  board: esp32dev
+
+binary_sensor:
+  - platform: gpio
+    pin: 5
+    name: "Interrupt Sensor"
+    id: bs_interrupt
+
+  - platform: gpio
+    pin: 4
+    name: "Polling Sensor"
+    id: bs_polling
+    use_interrupt: false