diff --git a/esphome/components/sx1509/__init__.py b/esphome/components/sx1509/__init__.py
index b61b92fd1e..5b904bb1a6 100644
--- a/esphome/components/sx1509/__init__.py
+++ b/esphome/components/sx1509/__init__.py
@@ -5,6 +5,7 @@ import esphome.config_validation as cv
 from esphome.const import (
     CONF_ID,
     CONF_INPUT,
+    CONF_INTERRUPT_PIN,
     CONF_INVERTED,
     CONF_MODE,
     CONF_NUMBER,
@@ -75,6 +76,7 @@ CONFIG_SCHEMA = (
         {
             cv.GenerateID(): cv.declare_id(SX1509Component),
             cv.Optional(CONF_KEYPAD): cv.Schema(KEYPAD_SCHEMA),
+            cv.Optional(CONF_INTERRUPT_PIN): pins.internal_gpio_input_pin_schema,
         }
     )
     .extend(cv.COMPONENT_SCHEMA)
@@ -86,6 +88,8 @@ async def to_code(config):
     var = cg.new_Pvariable(config[CONF_ID])
     await cg.register_component(var, config)
     await i2c.register_i2c_device(var, config)
+    if interrupt_pin := config.get(CONF_INTERRUPT_PIN):
+        cg.add(var.set_interrupt_pin(await cg.gpio_pin_expression(interrupt_pin)))
     if conf := config.get(CONF_KEYPAD):
         cg.add(var.set_rows_cols(conf[CONF_KEY_ROWS], conf[CONF_KEY_COLUMNS]))
         if (
diff --git a/esphome/components/sx1509/sx1509.cpp b/esphome/components/sx1509/sx1509.cpp
index 1cdae76eaf..0739fa1ef9 100644
--- a/esphome/components/sx1509/sx1509.cpp
+++ b/esphome/components/sx1509/sx1509.cpp
@@ -28,10 +28,23 @@ void SX1509Component::setup() {
   delayMicroseconds(500);
   if (this->has_keypad_)
     this->setup_keypad_();
+
+  if (this->interrupt_pin_ != nullptr) {
+    this->interrupt_pin_->setup();
+    this->interrupt_pin_->attach_interrupt(&SX1509Component::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
+    this->set_invalidate_on_read_(false);
+  }
+  // Disable loop until an input pin is configured via pin_mode()
+  // or keypad is active. For interrupt-driven mode, loop is re-enabled by the ISR.
+  if (!this->has_keypad_) {
+    this->disable_loop();
+  }
 }
 
+void IRAM_ATTR SX1509Component::gpio_intr(SX1509Component *arg) { arg->enable_loop_soon_any_context(); }
 void SX1509Component::dump_config() {
   ESP_LOGCONFIG(TAG, "SX1509:");
+  LOG_PIN("  Interrupt Pin: ", this->interrupt_pin_);
   if (this->is_failed()) {
     ESP_LOGE(TAG, "Setting up SX1509 failed!");
   }
@@ -41,6 +54,9 @@ void SX1509Component::dump_config() {
 void SX1509Component::loop() {
   // Reset cache at the start of each loop
   this->reset_pin_cache_();
+  if (this->interrupt_pin_ != nullptr && !this->has_keypad_) {
+    this->disable_loop();
+  }
 
   if (this->has_keypad_) {
     if (millis() - this->last_loop_timestamp_ < min_loop_period_)
@@ -169,6 +185,9 @@ void SX1509Component::pin_mode(uint8_t pin, gpio::Flags flags) {
     // Set direction to input
     this->ddr_mask_ |= (1 << pin);
     this->write_byte_16(REG_DIR_B, this->ddr_mask_);
+    if (this->interrupt_pin_ == nullptr) {
+      this->enable_loop();
+    }
   }
 }
 
diff --git a/esphome/components/sx1509/sx1509.h b/esphome/components/sx1509/sx1509.h
index f98fc0a44f..964a02dd52 100644
--- a/esphome/components/sx1509/sx1509.h
+++ b/esphome/components/sx1509/sx1509.h
@@ -46,6 +46,7 @@ class SX1509Component : public Component,
   uint16_t read_key_data();
   void set_pin_value(uint8_t pin, uint8_t i_on) { this->write_byte(REG_I_ON[pin], i_on); };
   void pin_mode(uint8_t pin, gpio::Flags flags);
+  void set_interrupt_pin(InternalGPIOPin *pin) { this->interrupt_pin_ = pin; }
   uint32_t get_clock() { return this->clk_x_; };
   void set_rows_cols(uint8_t rows, uint8_t cols) {
     this->rows_ = rows;
@@ -63,6 +64,8 @@ class SX1509Component : public Component,
   void setup_led_driver(uint8_t pin);
 
  protected:
+  static void IRAM_ATTR gpio_intr(SX1509Component *arg);
+
   // Virtual methods from CachedGpioExpander
   bool digital_read_hw(uint8_t pin) override;
   bool digital_read_cache(uint8_t pin) override;
@@ -85,6 +88,7 @@ class SX1509Component : public Component,
   std::vector<SX1509Processor *> keypad_binary_sensors_;
   std::vector<SX1509KeyTrigger *> key_triggers_;
 
+  InternalGPIOPin *interrupt_pin_{nullptr};
   uint32_t last_loop_timestamp_ = 0;
   const uint32_t min_loop_period_ = 15;  // ms
 
diff --git a/tests/components/sx1509/common.yaml b/tests/components/sx1509/common.yaml
index cf7e234f09..7bcd565864 100644
--- a/tests/components/sx1509/common.yaml
+++ b/tests/components/sx1509/common.yaml
@@ -2,6 +2,7 @@ sx1509:
   - id: sx1509_hub
     i2c_id: i2c_bus
     address: 0x3E
+    interrupt_pin: ${interrupt_pin}
     keypad:
       key_rows: 2
       key_columns: 2
diff --git a/tests/components/sx1509/test.esp32-idf.yaml b/tests/components/sx1509/test.esp32-idf.yaml
index b47e39c389..8c3b341dce 100644
--- a/tests/components/sx1509/test.esp32-idf.yaml
+++ b/tests/components/sx1509/test.esp32-idf.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
 
diff --git a/tests/components/sx1509/test.esp8266-ard.yaml b/tests/components/sx1509/test.esp8266-ard.yaml
index 4a98b9388a..69b243bfd8 100644
--- a/tests/components/sx1509/test.esp8266-ard.yaml
+++ b/tests/components/sx1509/test.esp8266-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp8266-ard.yaml
 
diff --git a/tests/components/sx1509/test.rp2040-ard.yaml b/tests/components/sx1509/test.rp2040-ard.yaml
index 319a7c71a6..b8ad1e4792 100644
--- a/tests/components/sx1509/test.rp2040-ard.yaml
+++ b/tests/components/sx1509/test.rp2040-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO2
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml