diff --git a/esphome/components/bme680_bsec/__init__.py b/esphome/components/bme680_bsec/__init__.py
index a86e061cd4..2365f8d107 100644
--- a/esphome/components/bme680_bsec/__init__.py
+++ b/esphome/components/bme680_bsec/__init__.py
@@ -6,6 +6,7 @@ from esphome.const import CONF_ID, CONF_SAMPLE_RATE, CONF_TEMPERATURE_OFFSET, Fr
 CODEOWNERS = ["@trvrnrth"]
 DEPENDENCIES = ["i2c"]
 AUTO_LOAD = ["sensor", "text_sensor"]
+CONFLICTS_WITH = ["bme68x_bsec2"]
 MULTI_CONF = True
 
 CONF_BME680_BSEC_ID = "bme680_bsec_id"
diff --git a/esphome/components/bme68x_bsec2/__init__.py b/esphome/components/bme68x_bsec2/__init__.py
index b56217fac1..5083d283ef 100644
--- a/esphome/components/bme68x_bsec2/__init__.py
+++ b/esphome/components/bme68x_bsec2/__init__.py
@@ -13,6 +13,7 @@ from esphome.const import (
 )
 
 CODEOWNERS = ["@neffs", "@kbx81"]
+CONFLICTS_WITH = ["bme680_bsec"]
 
 DOMAIN = "bme68x_bsec2"