diff --git a/esphome/components/esp8266/helpers.cpp b/esphome/components/esp8266/helpers.cpp
index 4c849948fd..2153ee944b 100644
--- a/esphome/components/esp8266/helpers.cpp
+++ b/esphome/components/esp8266/helpers.cpp
@@ -12,7 +12,8 @@ namespace esphome {
 uint32_t random_uint32() { return os_random(); }
 bool random_bytes(uint8_t *data, size_t len) { return os_get_random(data, len) == 0; }
 
-// ESP8266 Mutex is defined inline in helpers.h when ESPHOME_THREAD_SINGLE is set.
+// ESP8266 Mutex is defined inline as a no-op in helpers.h when USE_ESP8266 (or USE_RP2040) is set,
+// independent of the ESPHOME_THREAD_SINGLE thread model define.
 
 IRAM_ATTR InterruptLock::InterruptLock() { state_ = xt_rsil(15); }
 IRAM_ATTR InterruptLock::~InterruptLock() { xt_wsr_ps(state_); }