diff --git a/esphome/components/cc1101/cc1101.cpp b/esphome/components/cc1101/cc1101.cpp
index 7e5309e1659..fe9238b1411 100644
--- a/esphome/components/cc1101/cc1101.cpp
+++ b/esphome/components/cc1101/cc1101.cpp
@@ -140,7 +140,10 @@ void CC1101Component::setup() {
     this->write_(static_cast<Register>(i));
   }
   this->set_output_power(this->output_power_requested_);
-  this->strobe_(Command::RX);
+  if (!this->enter_rx_()) {
+    this->mark_failed();
+    return;
+  }
 
   // Defer pin mode setup until after all components have completed setup()
   // This handles the case where remote_transmitter runs after CC1101 and changes pin mode
@@ -163,8 +166,7 @@ void CC1101Component::loop() {
     ESP_LOGW(TAG, "RX FIFO overflow, flushing");
     this->enter_idle_();
     this->strobe_(Command::FRX);
-    this->strobe_(Command::RX);
-    this->wait_for_state_(State::RX);
+    this->enter_rx_();
     return;
   }
 
@@ -181,8 +183,7 @@ void CC1101Component::loop() {
     ESP_LOGW(TAG, "Invalid packet: rx_bytes %u, payload_length %u", rx_bytes, payload_length);
     this->enter_idle_();
     this->strobe_(Command::FRX);
-    this->strobe_(Command::RX);
-    this->wait_for_state_(State::RX);
+    this->enter_rx_();
     return;
   }
   this->packet_.resize(payload_length);
@@ -201,8 +202,7 @@ void CC1101Component::loop() {
   // Return to rx
   this->enter_idle_();
   this->strobe_(Command::FRX);
-  this->strobe_(Command::RX);
-  this->wait_for_state_(State::RX);
+  this->enter_rx_();
 }
 
 void CC1101Component::dump_config() {
@@ -233,9 +233,8 @@ void CC1101Component::begin_tx() {
   if (this->gdo0_pin_ != nullptr) {
     this->gdo0_pin_->pin_mode(gpio::FLAG_OUTPUT);
   }
-  this->strobe_(Command::TX);
-  if (!this->wait_for_state_(State::TX, 50)) {
-    ESP_LOGW(TAG, "Timed out waiting for TX state!");
+  if (!this->enter_tx_()) {
+    ESP_LOGW(TAG, "Failed to enter TX state!");
   }
 }
 
@@ -244,7 +243,9 @@ void CC1101Component::begin_rx() {
   if (this->gdo0_pin_ != nullptr) {
     this->gdo0_pin_->pin_mode(gpio::FLAG_INPUT);
   }
-  this->strobe_(Command::RX);
+  if (!this->enter_rx_()) {
+    ESP_LOGW(TAG, "Failed to enter RX state!");
+  }
 }
 
 void CC1101Component::reset() {
@@ -270,11 +271,33 @@ bool CC1101Component::wait_for_state_(State target_state, uint32_t timeout_ms) {
   return false;
 }
 
+bool CC1101Component::enter_calibrated_(State target_state, Command cmd) {
+  // The PLL must be recalibrated until PLL lock is achieved
+  for (uint8_t retries = PLL_LOCK_RETRIES; retries > 0; retries--) {
+    this->strobe_(cmd);
+    if (!this->wait_for_state_(target_state)) {
+      return false;
+    }
+    this->read_(Register::FSCAL1);
+    if (this->state_.FSCAL1 != FSCAL1_PLL_NOT_LOCKED) {
+      return true;
+    }
+    ESP_LOGW(TAG, "PLL lock failed, retrying calibration");
+    this->enter_idle_();
+  }
+  ESP_LOGE(TAG, "PLL lock failed after retries");
+  return false;
+}
+
 void CC1101Component::enter_idle_() {
   this->strobe_(Command::IDLE);
   this->wait_for_state_(State::IDLE);
 }
 
+bool CC1101Component::enter_rx_() { return this->enter_calibrated_(State::RX, Command::RX); }
+
+bool CC1101Component::enter_tx_() { return this->enter_calibrated_(State::TX, Command::TX); }
+
 uint8_t CC1101Component::strobe_(Command cmd) {
   uint8_t index = static_cast<uint8_t>(cmd);
   if (cmd < Command::RES || cmd > Command::NOP) {
@@ -336,18 +359,26 @@ CC1101Error CC1101Component::transmit_packet(const std::vector<uint8_t> &packet)
     this->write_(Register::FIFO, static_cast<uint8_t>(packet.size()));
   }
   this->write_(Register::FIFO, packet.data(), packet.size());
+
+  // Calibrate PLL
+  if (!this->enter_calibrated_(State::FSTXON, Command::FSTXON)) {
+    ESP_LOGW(TAG, "PLL lock failed during TX");
+    this->enter_idle_();
+    this->enter_rx_();
+    return CC1101Error::PLL_LOCK;
+  }
+
+  // Transmit packet
   this->strobe_(Command::TX);
   if (!this->wait_for_state_(State::IDLE, 1000)) {
     ESP_LOGW(TAG, "TX timeout");
     this->enter_idle_();
-    this->strobe_(Command::RX);
-    this->wait_for_state_(State::RX);
+    this->enter_rx_();
     return CC1101Error::TIMEOUT;
   }
 
   // Return to rx
-  this->strobe_(Command::RX);
-  this->wait_for_state_(State::RX);
+  this->enter_rx_();
   return CC1101Error::NONE;
 }
 
@@ -404,7 +435,7 @@ void CC1101Component::set_frequency(float value) {
     this->write_(Register::FREQ2);
     this->write_(Register::FREQ1);
     this->write_(Register::FREQ0);
-    this->strobe_(Command::RX);
+    this->enter_rx_();
   }
 }
 
@@ -431,7 +462,7 @@ void CC1101Component::set_channel(uint8_t value) {
   if (this->initialized_) {
     this->enter_idle_();
     this->write_(Register::CHANNR);
-    this->strobe_(Command::RX);
+    this->enter_rx_();
   }
 }
 
@@ -500,7 +531,7 @@ void CC1101Component::set_modulation_type(Modulation value) {
     this->set_output_power(this->output_power_requested_);
     this->write_(Register::MDMCFG2);
     this->write_(Register::FREND0);
-    this->strobe_(Command::RX);
+    this->enter_rx_();
   }
 }
 
diff --git a/esphome/components/cc1101/cc1101.h b/esphome/components/cc1101/cc1101.h
index b896f7e9742..fe4898660e7 100644
--- a/esphome/components/cc1101/cc1101.h
+++ b/esphome/components/cc1101/cc1101.h
@@ -9,7 +9,7 @@
 
 namespace esphome::cc1101 {
 
-enum class CC1101Error { NONE = 0, TIMEOUT, PARAMS, CRC_ERROR, FIFO_OVERFLOW };
+enum class CC1101Error { NONE = 0, TIMEOUT, PARAMS, CRC_ERROR, FIFO_OVERFLOW, PLL_LOCK };
 
 class CC1101Component : public Component,
                         public spi::SPIDevice<spi::BIT_ORDER_MSB_FIRST, spi::CLOCK_POLARITY_LOW,
@@ -102,7 +102,10 @@ class CC1101Component : public Component,
 
   // State Management
   bool wait_for_state_(State target_state, uint32_t timeout_ms = 100);
+  bool enter_calibrated_(State target_state, Command cmd);
   void enter_idle_();
+  bool enter_rx_();
+  bool enter_tx_();
 };
 
 // Action Wrappers
diff --git a/esphome/components/cc1101/cc1101defs.h b/esphome/components/cc1101/cc1101defs.h
index 1bc42f58599..59b29f7478f 100644
--- a/esphome/components/cc1101/cc1101defs.h
+++ b/esphome/components/cc1101/cc1101defs.h
@@ -9,6 +9,9 @@ static constexpr float XTAL_FREQUENCY = 26000000;
 static constexpr float RSSI_OFFSET = 74.0f;
 static constexpr float RSSI_STEP = 0.5f;
 
+static constexpr uint8_t FSCAL1_PLL_NOT_LOCKED = 0x3F;
+static constexpr uint8_t PLL_LOCK_RETRIES = 3;
+
 static constexpr uint8_t STATUS_CRC_OK_MASK = 0x80;
 static constexpr uint8_t STATUS_LQI_MASK = 0x7F;