diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index 3fc01c28775..42567bb7c93 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -129,6 +129,7 @@
 #define USE_WATER_HEATER
 #define USE_WATER_HEATER_VISUAL_OVERRIDES
 #define USE_ZIGBEE_PROXY
+#define USE_ZIGBEE_PROXY_USB_UART
 #define USE_ZWAVE_PROXY
 
 // Feature flags which do not work for zephyr