diff --git a/esphome/components/nextion/__init__.py b/esphome/components/nextion/__init__.py
index d51155b0a4..803d7a0dd2 100644
--- a/esphome/components/nextion/__init__.py
+++ b/esphome/components/nextion/__init__.py
@@ -19,7 +19,6 @@ FILTER_SOURCE_FILES = filter_source_files_from_platform(
         },
         "nextion_upload_arduino.cpp": {
             PlatformFramework.ESP8266_ARDUINO,
-            PlatformFramework.RP2_ARDUINO,
             PlatformFramework.BK72XX_ARDUINO,
             PlatformFramework.RTL87XX_ARDUINO,
             PlatformFramework.LN882X_ARDUINO,
diff --git a/esphome/components/nextion/display.py b/esphome/components/nextion/display.py
index 89e9b93520..b8971fd06f 100644
--- a/esphome/components/nextion/display.py
+++ b/esphome/components/nextion/display.py
@@ -4,7 +4,17 @@ from esphome import automation
 import esphome.codegen as cg
 from esphome.components import display, esp32, uart
 import esphome.config_validation as cv
-from esphome.const import CONF_BRIGHTNESS, CONF_ID, CONF_LAMBDA, CONF_ON_TOUCH
+from esphome.const import (
+    CONF_BRIGHTNESS,
+    CONF_ID,
+    CONF_LAMBDA,
+    CONF_ON_TOUCH,
+    PLATFORM_BK72XX,
+    PLATFORM_ESP32,
+    PLATFORM_ESP8266,
+    PLATFORM_LN882X,
+    PLATFORM_RTL87XX,
+)
 from esphome.core import CORE, TimePeriod
 
 from . import (  # noqa: F401  pylint: disable=unused-import
@@ -135,7 +145,20 @@ CONFIG_SCHEMA = cv.All(
             cv.Optional(
                 CONF_TFT_UPLOAD_WATCHDOG_TIMEOUT
             ): cv.positive_time_period_milliseconds,
-            cv.Optional(CONF_TFT_URL): cv.url,
+            # TFT upload needs an HTTP client and runtime UART reconfiguration,
+            # neither of which is implemented for the RP2 or host platforms.
+            cv.Optional(CONF_TFT_URL): cv.All(
+                cv.url,
+                cv.only_on(
+                    [
+                        PLATFORM_ESP32,
+                        PLATFORM_ESP8266,
+                        PLATFORM_BK72XX,
+                        PLATFORM_RTL87XX,
+                        PLATFORM_LN882X,
+                    ]
+                ),
+            ),
             cv.Optional(CONF_TOUCH_SLEEP_TIMEOUT): cv.Any(
                 0, cv.int_range(min=3, max=65535)
             ),
diff --git a/esphome/components/nextion/nextion.h b/esphome/components/nextion/nextion.h
index 29cadf979b..aa9fe8abb3 100644
--- a/esphome/components/nextion/nextion.h
+++ b/esphome/components/nextion/nextion.h
@@ -1566,7 +1566,7 @@ class Nextion final : public NextionBase, public PollingComponent, public uart::
    * @return position of last byte transferred, -1 for failure.
    */
   int upload_by_chunks_(esp_http_client_handle_t http_client, uint32_t &range_start);
-#elif defined(USE_ARDUINO)
+#elif defined(USE_ESP8266) || defined(USE_LIBRETINY)
   /**
    * will request chunk_size chunks from the web server
    * and send each to the nextion
@@ -1575,7 +1575,7 @@ class Nextion final : public NextionBase, public PollingComponent, public uart::
    * @return position of last byte transferred, -1 for failure.
    */
   int upload_by_chunks_(HTTPClient &http_client, uint32_t &range_start);
-#endif  // USE_ESP32 vs USE_ARDUINO
+#endif  // USE_ESP32 vs USE_ESP8266/USE_LIBRETINY
 
   /**
    * Ends the upload process, restart Nextion and, if successful,
diff --git a/esphome/components/nextion/nextion_upload_arduino.cpp b/esphome/components/nextion/nextion_upload_arduino.cpp
index 41379c2345..2b1039fef7 100644
--- a/esphome/components/nextion/nextion_upload_arduino.cpp
+++ b/esphome/components/nextion/nextion_upload_arduino.cpp
@@ -1,7 +1,7 @@
 #include "nextion.h"
 
 #ifdef USE_NEXTION_TFT_UPLOAD
-#ifndef USE_ESP32
+#if defined(USE_ESP8266) || defined(USE_LIBRETINY)
 
 #include <cinttypes>
 #include "esphome/components/network/util.h"
@@ -378,5 +378,5 @@ WiFiClient *Nextion::get_wifi_client_() {
 
 }  // namespace esphome::nextion
 
-#endif  // NOT USE_ESP32
+#endif  // USE_ESP8266 || USE_LIBRETINY
 #endif  // USE_NEXTION_TFT_UPLOAD